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Mutlu, Gokhan M.
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overview Dr. Mutlu is Professor of Medicine and Chief of the Section of Pulmonary and Critical Care Medicine at the University of Chicago. He is also the principal investigator/director of the NIH T32 Research training in respiratory biology. Dr. Mutlu's research focuses on the mechanisms of acute lung injury, and pulmonary fibrosis. Specifically, his laboratory is interested in understanding the role of macrophage and fibroblast metabolism including mitochondria in the pathogenesis of acute lung injury and pulmonary fibrosis. Dr. Mutlu's laboratory has extensive expertise with in vitro cell based methods including bioenergetics and in vivo models of acute lung injury (influenza, LPS, bacterial pneumonia and particulate matter) and pulmonary fibrosis (bleomycin).
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Concept Sodium-Potassium-Exchanging ATPase
Concept Amino Acid Sequence
Concept Barium Sulfate
Concept Base Sequence
Concept Brain Stem
Concept Central Nervous System Depressants
Concept Extracellular Space
Concept Genes, Recessive
Concept Humic Substances
Concept Particle Size
Concept Hypnotics and Sedatives
Concept Organ Size
Concept Pulmonary Surfactants
Concept Intensive Care Units
Concept Nervous System Diseases
Concept Salicylates
Concept Shock, Septic
Concept Silicon Dioxide
Concept Stress, Physiological
Concept Receptors, Cell Surface
Concept Cohort Studies
Concept Scleroderma, Systemic
Concept Smoking
Concept Sodium
Concept Sarcoidosis
Concept Serotonin
Concept Status Asthmaticus
Concept Sensitivity and Specificity
Concept Splenic Diseases
Concept Suicide
Concept Swine
Concept Skin
Concept Sodium Cyanide
Concept Spine
Concept Stress, Mechanical
Concept Succinates
Concept Superoxides
Concept Specific Pathogen-Free Organisms
Concept Stem Cells
Concept Genome
Concept United States
Concept Stroke Volume
Concept Superoxide Dismutase
Concept Syndrome
Concept Tobacco Smoke Pollution
Concept Myocardial Stunning
Concept Urban Population
Concept Sodium Channels
Concept Hematopoietic Stem Cell Transplantation
Concept Sleep Apnea, Obstructive
Concept Up-Regulation
Concept Rats, Sprague-Dawley
Concept Mutagenesis, Site-Directed
Concept Case-Control Studies
Concept Oxidative Stress
Concept Sepsis
Concept Transgenes
Concept Sleep Apnea, Central
Concept Metabolic Syndrome
Concept Cross-Over Studies
Concept Reactive Oxygen Species
Concept Sirtuin 3
Concept Serpin E2
Concept Single-Cell Analysis
Concept STAT Transcription Factors
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Concept Catalytic Domain
Concept Influenza A Virus, H3N2 Subtype
Concept Respiratory System
Concept Sclerosing Solutions
Concept Serine
Concept Serum Albumin
Concept Severity of Illness Index
Concept Specimen Handling
Concept Spinocerebellar Degenerations
Concept Sulfonamides
Concept Ubiquitin-Protein Ligases
Concept SKP Cullin F-Box Protein Ligases
Concept Propensity Score
Concept TOR Serine-Threonine Kinases
Concept Soccer
Concept Influenza A Virus, H1N1 Subtype
Concept Epithelial Sodium Channels
Concept Splanchnic Circulation
Concept Spleen
Concept Staphylococcus aureus
Concept Survival Analysis
Concept Survival Rate
Concept Genes, p53
Concept Cellular Senescence
Concept In Situ Nick-End Labeling
Concept Ubiquitin
Concept Wasting Syndrome
Concept Thoracic Surgery, Video-Assisted
Concept MAP Kinase Signaling System
Concept Extracellular Signal-Regulated MAP Kinases
Concept Tumor Suppressor Proteins
Concept Transcriptome
Concept RNA, Small Interfering
Concept Protein Inhibitors of Activated STAT
Concept National Institute of Environmental Health Sciences (U.S.)
Concept Cell Survival
Concept Mice, Mutant Strains
Concept Prospective Studies
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Concept Smoke
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Concept Signal Transduction
Concept Sequence Analysis, RNA
Concept Antidepressive Agents, Second-Generation
Concept Smad Proteins
Academic Article An unresponsive biochemistry professor in the bathtub.
Academic Article Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
Academic Article Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.
Academic Article Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling.
Academic Article Adenosine regulation of alveolar fluid clearance.
Academic Article Head CT is of limited diagnostic value in critically ill patients who remain unresponsive after discontinuation of sedation.
Academic Article beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats.
Academic Article Lung-specific loss of the laminin a3 subunit confers resistance to mechanical injury.
Academic Article Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity.
Academic Article Proteasomal regulation of pulmonary fibrosis.
Academic Article The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death.
Academic Article Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury.
Academic Article Leptin resistance protects mice from hyperoxia-induced acute lung injury.
Academic Article Pseudohypoxemia: interpretation of discrepancies between SaO(2) and SpO(2).
Academic Article The saga of obstructive sleep apnea syndrome and daytime hypercapnia: work in progress.
Academic Article Risk assessment for inpatient survival in the long-term acute care setting after prolonged critical illness.
Academic Article Linking air pollution exposure with thrombosis.
Academic Article Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury.
Academic Article Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.
Academic Article Air pollution impairs lung's ability to clear edema fluid.
Academic Article Pulmonary tumor embolism of unknown origin.
Academic Article Hyperalbuminemia and elevated transaminases associated with high-protein diet.
Academic Article Proapoptotic Bid is required for pulmonary fibrosis.
Academic Article Incidence and outcomes of acute lung injury.
Academic Article Images in clinical medicine. Splenic and mediastinal calcifications in histoplasmosis.
Academic Article Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport.
Academic Article A 41-year-old man with altered mental status and acute flaccid paralysis.
Academic Article beta(2)-Agonists for treatment of pulmonary edema: ready for clinical studies?
Academic Article Role of vasopressin in the management of septic shock.
Academic Article Acute lung injury does not impair adenoviral-mediated gene transfer to the alveolar epithelium.
Academic Article Acute hyperoxic lung injury does not impede adenoviral-mediated alveolar gene transfer.
Academic Article Complications of mechanical ventilation.
Academic Article Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-d.
Academic Article Mitochondrial reactive oxygen species regulate transforming growth factor-ß signaling.
Academic Article The effect of rosuvastatin in a murine model of influenza A infection.
Academic Article Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.
Academic Article Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice.
Academic Article Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms.
Academic Article Dysphonia and chest pain as presenting symptoms of pneumomediastinum.
Academic Article Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.
Academic Article Alveolar epithelial beta2-adrenergic receptors.
Academic Article Alveolar epithelial beta 2-adrenergic receptors: their role in regulation of alveolar active sodium transport.
Academic Article Comparison of surfactant and perfluorochemical liquid enhanced adenovirus-mediated gene transfer in normal rat lung.
Academic Article Collection and analysis of exhaled breath condensate in humans.
Academic Article Obstructive sleep apnea syndrome-associated nocturnal myocardial ischemia.
Academic Article Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.
Academic Article Nuclear ß-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.
Academic Article Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-?.
Academic Article Coma with absent brainstem reflexes resulting from zolpidem overdose.
Academic Article Adenosine A1 receptor, a target and regulator of estrogen receptoralpha action, mediates the proliferative effects of estradiol in breast cancer.
Academic Article Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.
Academic Article Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways.
Academic Article Predictors of acute lung injury and severe hypoxemia in patients undergoing operative talc pleurodesis.
Academic Article p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis.
Academic Article Images in cardiovascular medicine. Pulmonary embolization of acrylic cement during vertebroplasty.
Academic Article Reply: ß2-agonists and acute respiratory distress syndrome.
Academic Article ß2-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis.
Academic Article PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.
Academic Article Sequestration of mitochondrial iron by silica particle initiates a biological effect.
Academic Article Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan.
Academic Article Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway.
Academic Article Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor.
Academic Article Proteasomal inhibition after injury prevents fibrosis by modulating TGF-ß(1) signalling.
Academic Article Lung-specific loss of a3 laminin worsens bleomycin-induced pulmonary fibrosis.
Academic Article Loss of TLR4 does not prevent influenza A-induced mortality.
Academic Article Markers of prognosis specific to influenza infection: are we there yet?
Academic Article ß2-agonists and acute respiratory distress syndrome.
Academic Article Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung.
Academic Article Toll-like receptor 4 signaling augments transforming growth factor-ß responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma.
Academic Article Update in environmental and occupational medicine 2010.
Academic Article Joubert syndrome associated with severe central sleep apnea.
Academic Article Update in environmental and occupational medicine 2009.
Academic Article Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
Academic Article Not much turbulence: addition of heliox to noninvasive ventilation fails to improve outcomes in patients with exacerbations of chronic obstructive pulmonary disease.
Academic Article Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.
Academic Article Stretch-induced activation of AMP kinase in the lung requires dystroglycan.
Academic Article Severe pseudomonal infections.
Academic Article Clinical manifestations of sarcoidosis among inner-city African-American dwellers.
Academic Article Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation.
Academic Article Cerebrospinal fluid leak and meningitis associated with nasal continuous positive airway pressure therapy.
Academic Article Effects of body temperature on ventilator-induced lung injury.
Academic Article Potential genetic therapies for acute lung injury.
Academic Article Gastric intramucosal pH is stable during titration of positive end-expiratory pressure to improve oxygenation in acute respiratory distress syndrome.
Academic Article Effects of beta2-adrenergic receptor overexpression on alveolar epithelial active transport.
Academic Article Acute-onset quadriplegia, respiratory failure, and ventricular tachycardia in a 21-year-old man following a soccer match.
Academic Article Enhancement of alveolar epithelial beta(2)-adrenergic receptor function via gene transfer.
Academic Article Severe status asthmaticus: management with permissive hypercapnia and inhalation anesthesia.
Academic Article GI complications in patients receiving mechanical ventilation.
Academic Article ß2-Agonist therapy may contribute to the air pollution and IL-6-associated risk of developing severe asthma with dual-positive TH2/TH17 cells.
Academic Article Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.
Academic Article Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction.
Academic Article Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus.
Academic Article SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
Academic Article Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production.
Academic Article Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.
Academic Article Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase.
Academic Article PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes.
Academic Article Prolonged Exposures to Intermittent Hypoxia Promote Visceral White Adipose Tissue Inflammation in a Murine Model of Severe Sleep Apnea: Effect of Normoxic Recovery.
Academic Article HIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.
Academic Article Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.
Academic Article Wandering Pleural Mesothelial Fatty Cyst.
Academic Article Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.
Academic Article Nitric oxide prevents alveolar senescence and emphysema in a mouse model.
Academic Article Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect.
Academic Article Regulation of allergic lung inflammation by endothelial cell transglutaminase 2.
Academic Article Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Academic Article Alveolar Epithelial Cells Burn Fat to Survive Acute Lung Injury.
Academic Article African-American race and mortality in interstitial lung disease: a multicentre propensity-matched analysis.
Academic Article Letter by Mutlu and Budinger Regarding Article, "Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification".
Academic Article Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.
Academic Article Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.
Academic Article The NIEHS TaRGET II Consortium and environmental epigenomics.
Academic Article P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation.
Academic Article Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1a Drives Endothelial Dysfunction at Atheroprone Sites".
Academic Article Particulate Matter Air Pollution: Effects on the Cardiovascular System.
Academic Article Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.
Academic Article Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
Grant Particulate matter-induced changes in DNA methylome and transcriptome
Academic Article Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Academic Article Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes.
Academic Article Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response.
Academic Article The Airway Epithelial Response to Air Pollution: It's Not Just Inflammation.
Academic Article Update in Chronic Obstructive Pulmonary Disease 2018.
Academic Article TGF-ß Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
Academic Article Late onset infectious complications and safety of tocilizumab in the management of COVID-19.
Academic Article IL6 inhibition in critically ill COVID-19 patients is associated with increased secondary infections.
Academic Article IL-6 Inhibition in Critically Ill COVID-19 Patients Is Associated With Increased Secondary Infections.
Academic Article SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy.
Academic Article The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer.
Academic Article SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy.
Academic Article Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells.
Academic Article Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release.
Grant Role of alveolar macrophages in particulate matter-induced cardiopulmonary disease
Grant Integrative Consequences of Intermittent Hypoxia
Grant ChicAgo Center for Health and EnvironmenT (CACHET)
Academic Article Update in Critical Care 2020.
Academic Article The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging.
Academic Article Geotrichum infection in an immunocompetent host with SARS-CoV-2 infection.
Concept Salmeterol Xinafoate
Concept Stromal Interaction Molecule 1
Concept Superoxide Dismutase-1
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